Midway through his job, Cees Dekker reinvented himself. Following yrs of hardcore physics, he shifted his concentrate to ‘nanobiology’ for the flip with the millennium. A term he coined himself, for a matter of simple fact.
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Like a individual, I provide the biblical assignment to explore and use almost everything in generation for the good thing about my neighbour. I don't knowledge any conflict concerning faith and science. On the contrary, my religion stimulates me to carry out science, to be open-minded on earth.’
Deposition and atomic power microscopy of person phthalocyanine polymers in between nanofabricated electrodes
2015, discovery that condensin is actually a extremely adaptable protein construction; and first detection of DNA knots applying nanopores
SMC complexes can go Bodily roadblocks bigger than their ring dimension, indicating a nontopological system for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which evaluate the fundamental function of spatial confinement in the molecular and cellular amount. Our jobs involve the subsequent:
Illustration (one) of bending configurations in 3D simulations of DNA rods ceesdekker.net on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement from the DNA rod is shown.
The rotors harness energy from the nanoscale drinking water and ion movement that's produced by a static chemical or electrochemical possible gradient from the nanopore, which can be established via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and work autonomously in physiological ailments, suggesting approaches to constructing Electrical power-transducing motors at nanoscale interfaces.
Bulk-floor coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro
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2008, very first observation of protein-coated DNA translocation by means of nanopores; resolved the origin of your electrophoretic pressure on DNA in nanopores; uncovered an important velocity maximize of microtubules in electric fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of noise in carbon nanotubes in liquid
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Houses of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.